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Intrarenal angiotensinogen: localization and regulation.

Publication ,  Journal Article
Ingelfinger, JR; Schunkert, H; Ellison, KE; Pivor, M; Zuo, WM; Pratt, R; Dzau, VJ
Published in: Pediatr Nephrol
July 1990

Multiple lines of evidence (physiologic, immunohistochemical, and molecular biologic) support the presence of a complete intrarenal renin-angiotensin system (RAS). Localization of angiotensinogen messenger ribonucleic acid (mRNA) within the proximal tubule, together with demonstration of renin and converting enzyme mRNAs within the kidney, provide the most persuasive evidence for local, independent synthesis. Data from a combination of in situ hybridization studies, Northern analysis, and physiologic manipulations lead us to propose that a major site for action of a local RAS is the proximal tubule. There, locally generated angiotensins may regulate sodium reabsorption and urine pH. A variety of factors appear to regulate renal angiotensinogen. For instance sodium depletion increases the expression of renal angiotensinogen (as well as renin mRNA), as does high potassium intake and androgen administration. In pathologic states, such as experimental heart failure, and certain models of hypertension, such as the spontaneously hypertensive rat, expression of renal angiotensinogen mRNA levels is altered. It is proposed that changes in the intrarenal RAS may play a role in the maintenance of homeostasis and in the pathophysiology of various disease states.

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Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

July 1990

Volume

4

Issue

4

Start / End Page

424 / 428

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Kidney
  • Humans
  • Animals
  • Angiotensinogen
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
 

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Ingelfinger, J. R., Schunkert, H., Ellison, K. E., Pivor, M., Zuo, W. M., Pratt, R., & Dzau, V. J. (1990). Intrarenal angiotensinogen: localization and regulation. Pediatr Nephrol, 4(4), 424–428. https://doi.org/10.1007/BF00862530
Ingelfinger, J. R., H. Schunkert, K. E. Ellison, M. Pivor, W. M. Zuo, R. Pratt, and V. J. Dzau. “Intrarenal angiotensinogen: localization and regulation.Pediatr Nephrol 4, no. 4 (July 1990): 424–28. https://doi.org/10.1007/BF00862530.
Ingelfinger JR, Schunkert H, Ellison KE, Pivor M, Zuo WM, Pratt R, et al. Intrarenal angiotensinogen: localization and regulation. Pediatr Nephrol. 1990 Jul;4(4):424–8.
Ingelfinger, J. R., et al. “Intrarenal angiotensinogen: localization and regulation.Pediatr Nephrol, vol. 4, no. 4, July 1990, pp. 424–28. Pubmed, doi:10.1007/BF00862530.
Ingelfinger JR, Schunkert H, Ellison KE, Pivor M, Zuo WM, Pratt R, Dzau VJ. Intrarenal angiotensinogen: localization and regulation. Pediatr Nephrol. 1990 Jul;4(4):424–428.
Journal cover image

Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

July 1990

Volume

4

Issue

4

Start / End Page

424 / 428

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Kidney
  • Humans
  • Animals
  • Angiotensinogen
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine