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Vascular angiotensin pathways: a new therapeutic target.

Publication ,  Journal Article
Dzau, VJ
Published in: J Cardiovasc Pharmacol
1987

The renin-angiotensin system affects blood pressure and regional blood flow through endocrine, paracrine, and autocrine influences. The circulating endocrine renin-angiotensin system (RAS) is activated for acute cardiovascular homeostasis. The recent demonstration of a local renin-angiotensin system in the blood vessel wall has led us to speculate that the local production of angiotensin is involved with autocrine and paracrine control of vascular resistance. In addition to producing arteriolar constriction, arterial wall renin-angiotensin may influence the compliance of large conduit arteries. The production of angiotensin in the blood vessels may participate in hypertension and may influence blood pressure responses to the inhibitors of the RAS.

Duke Scholars

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

1987

Volume

10 Suppl 7

Start / End Page

S9 / 16

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Renin-Angiotensin System
  • Humans
  • Homeostasis
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Arteries
  • Angiotensin II
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Dzau, V. J. (1987). Vascular angiotensin pathways: a new therapeutic target. J Cardiovasc Pharmacol, 10 Suppl 7, S9-16.
Dzau, V. J. “Vascular angiotensin pathways: a new therapeutic target.J Cardiovasc Pharmacol 10 Suppl 7 (1987): S9-16.
Dzau VJ. Vascular angiotensin pathways: a new therapeutic target. J Cardiovasc Pharmacol. 1987;10 Suppl 7:S9-16.
Dzau, V. J. “Vascular angiotensin pathways: a new therapeutic target.J Cardiovasc Pharmacol, vol. 10 Suppl 7, 1987, pp. S9-16.
Dzau VJ. Vascular angiotensin pathways: a new therapeutic target. J Cardiovasc Pharmacol. 1987;10 Suppl 7:S9-16.

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

1987

Volume

10 Suppl 7

Start / End Page

S9 / 16

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Renin-Angiotensin System
  • Humans
  • Homeostasis
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Arteries
  • Angiotensin II
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology