Clinical response to angiotensin-converting enzyme inhibition in cardiac failure.

Journal Article (Journal Article;Review)

The renin-angiotensin system plays a pivotal role in the pathophysiology of heart failure. ACE inhibitors block the production of angiotensin II and are efficacious in the therapy of patients with heart failure, ACE inhibitors have combined preload and afterload reducing effects. Cardiac index is augmented, cardiac filling pressures are reduced and renal function may improve with ACE inhibition. Long-term subjective and objective improvements have been reported. Preliminary data suggest that this class of vasodilators may favorably influence the prognosis of advanced heart failure.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ; Creager, MA

Published Date

  • 1987

Published In

Volume / Issue

  • 9 / 2-3

Start / End Page

  • 521 - 529

PubMed ID

  • 3038416

International Standard Serial Number (ISSN)

  • 0730-0077

Digital Object Identifier (DOI)

  • 10.3109/10641968709164220


  • eng

Conference Location

  • United States