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Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph.

Publication ,  Journal Article
Dzau, VJ; Wilcox, CS; Sands, K; Dunckel, P
Published in: Am J Physiol
January 1986

It has been suggested that the dog is a useful model for studies of inactive renin (IR). However, the nature and origin of the trypsin-activated angiotensin-forming activity in dog plasma have not been fully defined. We characterized dog IR using renin-specific antibody, immunoaffinity, and Affigel blue chromatography. Activated IR resembles renal and plasma active renin in biochemical and immunological properties. IR was detected in renal lymph, arterial and venous plasma, as well as renal extracts. At basal state, there was a significant renal venous-arterial gradient of IR indicating secretion from the kidney. Furthermore, a sixfold higher concentration of IR was demonstrated in renal lymph than in plasma. Our data provides evidence for two possible routes of IR secretion from the kidney and supports the contention that the dog is a good model for studies of IR secretion and regulation.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1986

Volume

250

Issue

1 Pt 1

Start / End Page

E55 / E61

Location

United States

Related Subject Headings

  • Trypsin
  • Renin
  • Regional Blood Flow
  • Lymph
  • Kidney
  • Hydrogen-Ion Concentration
  • Dogs
  • Chromatography, Affinity
  • Cardiovascular System & Hematology
  • Animals
 

Citation

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Dzau, V. J., Wilcox, C. S., Sands, K., & Dunckel, P. (1986). Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph. Am J Physiol, 250(1 Pt 1), E55–E61. https://doi.org/10.1152/ajpendo.1986.250.1.E55
Dzau, V. J., C. S. Wilcox, K. Sands, and P. Dunckel. “Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph.Am J Physiol 250, no. 1 Pt 1 (January 1986): E55–61. https://doi.org/10.1152/ajpendo.1986.250.1.E55.
Dzau VJ, Wilcox CS, Sands K, Dunckel P. Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph. Am J Physiol. 1986 Jan;250(1 Pt 1):E55–61.
Dzau, V. J., et al. “Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph.Am J Physiol, vol. 250, no. 1 Pt 1, Jan. 1986, pp. E55–61. Pubmed, doi:10.1152/ajpendo.1986.250.1.E55.
Dzau VJ, Wilcox CS, Sands K, Dunckel P. Dog inactive renin: biochemical characterization and secretion into renal plasma and lymph. Am J Physiol. 1986 Jan;250(1 Pt 1):E55–E61.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1986

Volume

250

Issue

1 Pt 1

Start / End Page

E55 / E61

Location

United States

Related Subject Headings

  • Trypsin
  • Renin
  • Regional Blood Flow
  • Lymph
  • Kidney
  • Hydrogen-Ion Concentration
  • Dogs
  • Chromatography, Affinity
  • Cardiovascular System & Hematology
  • Animals