Heat diffusion and chemical kinetics in Mark-III FEL tissue ablation

Published

Journal Article

We present in some detail a theoretical model that provides a dynamical account for the experimentally observed ablative properties of an FEL tuned near 6.45 microns. The model is based on thermal diffusion and chemical kinetics in a system of alternating layers of protein and saline as heated by an infrared Mark-III FEL. We compare exposure at 3.0 microns, where water is the sole absorber, to that at 6.45 microns, where both protein and water absorb. The picosecond pulses of the Mark-III superpulse are treated as a train of impulses. We consider the onset of both the helix-coil transition and chemical bond breaking in terms of the thermal, chemical, and mechanical properties of the system as well as laser wavelength and pulse structure.

Full Text

Duke Authors

Cited Authors

  • Edwards, GS; Shane Hutson, M; Hauger, S

Published Date

  • January 1, 2002

Published In

Volume / Issue

  • 4633 /

Start / End Page

  • 184 - 193

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.461378

Citation Source

  • Scopus