Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns


Journal Article

We have investigated the experimental consequences of two picosecond infrared lasers, both tuned to 6.45 μm and focused on ocular tissue. The exposure conditions were comparable, other than pulse repetition rate, where an optical parametric oscillator/amplifier laser (OPA) system operates at a kilohertz and the Mark-III FEL at 3 gigahertz. In both cases, the peak intensity was near 2×1014 W/m2 and the total delivered energy was approximately 125 mJ. The Mark-III consistently ablates tissue, while the OPA fails to ablate or to damage corneal tissue. In particular, there is no experimental evidence for protein denaturation due to OPA irradiation. We account for these observations in terms of a theoretical model based on thermal diffusion and threshold conditions for superheating and chemical kinetics. We comment on the relevance of tissue geometry.

Full Text

Duke Authors

Cited Authors

  • Edwards, G; Shane Hutson, M; Hauger, S; Kozub, J; Shen, J; Shieh, C; Topadze, K; Joos, K

Published Date

  • January 1, 2002

Published In

Volume / Issue

  • 4633 /

Start / End Page

  • 194 - 200

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.461379

Citation Source

  • Scopus