Tissue ablation by a free-electron laser tuned to the amide II band.

Journal Article (Journal Article)

Efforts to ablate soft tissue with conventional lasers have been limited by collateral damage and by concern over potential photochemical effects. Motivated by the thermal-confinement model, past infrared investigations targeted the OH-stretch mode of water with fast pulses from lasers emitting near 3,000 nm (refs 1, 7-9). What does a free-electron laser offer for the investigation of tissue ablation? Operating at non-photochemical single-photon energies, these infrared sources can produce trains of picosecond pulses tunable to the vibrational modes of proteins, lipids and/or water. We report here that targeting free-electron laser radiation to the amide II band of proteins leads to tissue ablation characterized by minimal collateral damage while maintaining a substantial ablation rate. To account for these observations we propose a novel ablation mechanism based on compromising tissue through resonant denaturation of structural proteins.

Full Text

Duke Authors

Cited Authors

  • Edwards, G; Logan, R; Copeland, M; Reinisch, L; Davidson, J; Johnson, B; Maciunas, R; Mendenhall, M; Ossoff, R; Tribble, J

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 371 / 6496

Start / End Page

  • 416 - 419

PubMed ID

  • 8090220

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/371416a0


  • eng