Processive and nonprocessive models of kinesin movement.

Journal Article (Journal Article;Review)

Conventional kinesin is the prototypic member of a family of diverse proteins that use the chemical energy of ATP hydrolysis to generate force and move along microtubules. These proteins, which are involved in a wide range of cellular functions, have been identified in protozoa, fungi, plants, and animals and possess a high degree of sequence conservation among species in their motor domains. The biochemical properties of kinesin and its homologues, in conjunction with the recently solved three-dimensional structures of several kinesin motors, have contributed to our understanding of the mechanism of kinesin movement along microtubules. We discuss several models for movement, including the hand-over-hand, inchworm, and biased diffusion models of processive movement, as well as models of nonprocessive movement.

Full Text

Duke Authors

Cited Authors

  • Endow, SA; Barker, DS

Published Date

  • 2003

Published In

Volume / Issue

  • 65 /

Start / End Page

  • 161 - 175

PubMed ID

  • 12208993

International Standard Serial Number (ISSN)

  • 0066-4278

Digital Object Identifier (DOI)

  • 10.1146/annurev.physiol.65.092101.142550


  • eng

Conference Location

  • United States