Directionality and processivity of molecular motors.

Journal Article (Journal Article;Review)

Analysis of a mutant with altered directionality has led to new insights into motor directionality. The prediction from current models for processivity of a two-heads-bound state has been confirmed by electron microscopy for myosin V and by unbinding experiments for kinesin. Evidence is emerging that non-processive motors bind their filament with one head, hydrolyze ATP and then release, requiring binding by a second motor to complete a step.

Full Text

Duke Authors

Cited Authors

  • Higuchi, H; Endow, SA

Published Date

  • February 2002

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 50 - 57

PubMed ID

  • 11792544

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/s0955-0674(01)00293-9


  • eng

Conference Location

  • England