Determinants of molecular motor directionality.

Journal Article (Journal Article;Review)

Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and the finding that the Ncd 'neck' can convert Ncd or kinesin, which are intrinsically plus-end-directed microtubule motors, into a minus-end motor. These findings raise several outstanding questions, foremost, how does the neck function in motor directionality?

Full Text

Duke Authors

Cited Authors

  • Endow, SA

Published Date

  • October 1999

Published In

Volume / Issue

  • 1 / 6

Start / End Page

  • E163 - E167

PubMed ID

  • 10559980

International Standard Serial Number (ISSN)

  • 1465-7392

Digital Object Identifier (DOI)

  • 10.1038/14113


  • eng

Conference Location

  • England