Kinesin proteins: a phylum of motors for microtubule-based motility.

Published

Journal Article (Review)

The cellular processes of transport, division and, possibly, early development all involve microtubule-based motors. Recent work shows that, unexpectedly, many of these cellular functions are carried out by different types of kinesin and kinesin-related motor proteins. The kinesin proteins are a large and rapidly growing family of microtubule-motor proteins that share a 340-amino-acid motor domain. Phylogenetic analysis of the conserved motor domains groups the kinesin proteins into a number of subfamilies, the members of which exhibit a common molecular organization and related functions. The kinesin proteins that belong to different subfamilies differ in their rates and polarity of movement along microtubules, and probably in the particles/organelles that they transport. The kinesins arose early in eukaryotic evolution and gene duplication has allowed functional specialization to occur, resulting in a surprisingly large number of different classes of these proteins adapted for intracellular transport of vesicles and organelles, and for assembly and force generation in the meiotic and mitotic spindles.

Full Text

Duke Authors

Cited Authors

  • Moore, JD; Endow, SA

Published Date

  • March 1996

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 207 - 219

PubMed ID

  • 8867735

Pubmed Central ID

  • 8867735

International Standard Serial Number (ISSN)

  • 0265-9247

Digital Object Identifier (DOI)

  • 10.1002/bies.950180308

Language

  • eng

Conference Location

  • United States