Mutant alleles of the meiotic locus, mei-9, differ in degree of effects on rod chromosome magnification and ring chromosome transmission in Drosophila.

Published

Journal Article

Two mutant alleles of the meiotic locus, mei-9, have been examined for their effect on magnification of a rod Xbb chromosome and transmission of a ring Xbb chromosome under magnifying conditions. Our results indicate that the effects of these two mutations are allele-specific: mei-9a strongly inhibits both rod chromosome magnification and ring chromosome loss under magnifying conditions, while mei-9b has a smaller inhibitory effect on rod chromosome magnification and on the transmission of ring chromosomes under magnifying conditions. These observations can be explained by a difference in leakiness between the two alleles. Our results demonstrate that mutants defective in excision repair and repair replication inhibit ribosomal gene magnification. This suggests that a component of the excision repair pathway is involved in the process of magnification.

Full Text

Duke Authors

Cited Authors

  • Komma, DJ; Graves, H; Endow, SA

Published Date

  • June 1989

Published In

  • Genet Res

Volume / Issue

  • 53 / 3

Start / End Page

  • 155 - 161

PubMed ID

  • 2504645

Pubmed Central ID

  • 2504645

Digital Object Identifier (DOI)

  • 10.1017/s0016672300028111

Language

  • eng

Conference Location

  • England