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Thrombospondins as key regulators of synaptogenesis in the central nervous system.

Publication ,  Journal Article
Risher, WC; Eroglu, C
Published in: Matrix Biol
April 2012

Thrombospondins (TSPs) are a family of large, oligomeric multidomain glycoproteins that participate in a variety of biological functions as part of the extracellular matrix (ECM). Through their associations with a number of binding partners, TSPs mediate complex cell-cell and cell-matrix interactions in such diverse processes as angiogenesis, inflammation, osteogenesis, cell proliferation, and apoptosis. It was recently shown in the developing central nervous system (CNS) that TSPs promote the formation of new synapses, which are the unique cell-cell adhesions between neurons in the brain. This increase in synaptogenesis is mediated by the interaction between astrocyte-secreted TSPs and their neuronal receptor, calcium channel subunit α2δ-1. The cellular and molecular mechanisms that underlie induction of synaptogenesis via this interaction are yet to be fully elucidated. This review will focus on what is known about TSP and synapse formation during development, possible roles for TSP following brain injury, and what the previously established actions of TSP in other biological tissues may tell us about the mechanisms underlying TSP's functions in CNS synaptogenesis.

Duke Scholars

Published In

Matrix Biol

DOI

EISSN

1569-1802

Publication Date

April 2012

Volume

31

Issue

3

Start / End Page

170 / 177

Location

Netherlands

Related Subject Headings

  • Thrombospondins
  • Signal Transduction
  • Receptors, Cell Surface
  • Models, Molecular
  • Humans
  • Electrical Synapses
  • Culture Media, Conditioned
  • Central Nervous System
  • Calcium Channels
  • Brain Injuries
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Risher, W. C., & Eroglu, C. (2012). Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol, 31(3), 170–177. https://doi.org/10.1016/j.matbio.2012.01.004
Risher, W Christopher, and Cagla Eroglu. “Thrombospondins as key regulators of synaptogenesis in the central nervous system.Matrix Biol 31, no. 3 (April 2012): 170–77. https://doi.org/10.1016/j.matbio.2012.01.004.
Risher WC, Eroglu C. Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol. 2012 Apr;31(3):170–7.
Risher, W. Christopher, and Cagla Eroglu. “Thrombospondins as key regulators of synaptogenesis in the central nervous system.Matrix Biol, vol. 31, no. 3, Apr. 2012, pp. 170–77. Pubmed, doi:10.1016/j.matbio.2012.01.004.
Risher WC, Eroglu C. Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol. 2012 Apr;31(3):170–177.
Journal cover image

Published In

Matrix Biol

DOI

EISSN

1569-1802

Publication Date

April 2012

Volume

31

Issue

3

Start / End Page

170 / 177

Location

Netherlands

Related Subject Headings

  • Thrombospondins
  • Signal Transduction
  • Receptors, Cell Surface
  • Models, Molecular
  • Humans
  • Electrical Synapses
  • Culture Media, Conditioned
  • Central Nervous System
  • Calcium Channels
  • Brain Injuries