Regulation of synaptic connectivity by glia.

Published

Journal Article (Review)

The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and elimination, both in health and disease. Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases.

Full Text

Duke Authors

Cited Authors

  • Eroglu, C; Barres, BA

Published Date

  • November 2010

Published In

Volume / Issue

  • 468 / 7321

Start / End Page

  • 223 - 231

PubMed ID

  • 21068831

Pubmed Central ID

  • 21068831

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature09612

Language

  • eng