Look who is weaving the neural web: glial control of synapse formation.

Published

Journal Article (Review)

Historically, our understanding of synapse formation has been shaped by studies focusing on neurons. However, with advancements in live imaging techniques and molecular and genetic tools we are rapidly uncovering new roles for glia in synapse formation and function. Contact-mediated signals from glia instruct dendrites to become receptive to synaptic partners. Glia-secreted factors coordinate the assembly and apposition of pre-synaptic and post-synaptic specializations. Glial cells also provide cues that are required for synaptic maturation and remodeling of spines both during development and in the adult. As we continue to learn about glial contributions to synapse formation and maintenance, it is likely that glia-derived signals will emerge as potential therapeutic targets for diseases that involve aberrant circuit function such as autism, epilepsy and Alzheimer's Disease.

Full Text

Duke Authors

Cited Authors

  • Bolton, MM; Eroglu, C

Published Date

  • October 2009

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 491 - 497

PubMed ID

  • 19879129

Pubmed Central ID

  • 19879129

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2009.09.007

Language

  • eng

Conference Location

  • England