Skip to main content
Journal cover image

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.

Publication ,  Journal Article
Liauw, J; Hoang, S; Choi, M; Eroglu, C; Choi, M; Sun, G-H; Percy, M; Wildman-Tobriner, B; Bliss, T; Guzman, RG; Barres, BA; Steinberg, GK
Published in: J Cereb Blood Flow Metab
October 2008

Thrombospondins 1 and 2 (TSP-1/2) belong to a family of extracellular glycoproteins with angiostatic and synaptogenic properties. Although TSP-1/2 have been postulated to drive the resolution of postischemic angiogenesis, their role in synaptic and functional recovery is unknown. We investigated whether TSP-1/2 are necessary for synaptic and motor recovery after stroke. Focal ischemia was induced in 8- to 12-week-old wild-type (WT) and TSP-1/2 knockout (KO) mice by unilateral occlusion of the distal middle cerebral artery and the common carotid artery (CCA). Thrombospondins 1 and 2 increased after stroke, with both TSP-1 and TSP-2 colocalizing mostly to astrocytes. Wild-type and TSP-1/2 KO mice were compared in angiogenesis, synaptic density, axonal sprouting, infarct size, and functional recovery at different time points after stroke. Using the tongue protrusion test of motor function, we observed that TSP-1/2 KO mice exhibited significant deficit in their ability to recover function (P<0.05) compared with WT mice. No differences were found in infarct size and blood vessel density between the two groups after stroke. However, TSP-1/2 KO mice exhibited significant synaptic density and axonal sprouting deficits. Deficiency of TSP-1/2 leads to impaired recovery after stroke mainly due to the role of these proteins in synapse formation and axonal outgrowth.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

October 2008

Volume

28

Issue

10

Start / End Page

1722 / 1732

Location

United States

Related Subject Headings

  • Up-Regulation
  • Thrombospondins
  • Thrombospondin 1
  • Synapses
  • Stroke
  • Recovery of Function
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Neovascularization, Physiologic
  • Mice, Knockout
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liauw, J., Hoang, S., Choi, M., Eroglu, C., Sun, G.-H., Percy, M., … Steinberg, G. K. (2008). Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab, 28(10), 1722–1732. https://doi.org/10.1038/jcbfm.2008.65
Liauw, Jason, Stanley Hoang, Michael Choi, Cagla Eroglu, Matthew Choi, Guo-hua Sun, Matthew Percy, et al. “Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.J Cereb Blood Flow Metab 28, no. 10 (October 2008): 1722–32. https://doi.org/10.1038/jcbfm.2008.65.
Liauw J, Hoang S, Choi M, Eroglu C, Sun G-H, Percy M, et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab. 2008 Oct;28(10):1722–32.
Liauw, Jason, et al. “Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.J Cereb Blood Flow Metab, vol. 28, no. 10, Oct. 2008, pp. 1722–32. Pubmed, doi:10.1038/jcbfm.2008.65.
Liauw J, Hoang S, Choi M, Eroglu C, Sun G-H, Percy M, Wildman-Tobriner B, Bliss T, Guzman RG, Barres BA, Steinberg GK. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab. 2008 Oct;28(10):1722–1732.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

October 2008

Volume

28

Issue

10

Start / End Page

1722 / 1732

Location

United States

Related Subject Headings

  • Up-Regulation
  • Thrombospondins
  • Thrombospondin 1
  • Synapses
  • Stroke
  • Recovery of Function
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Neovascularization, Physiologic
  • Mice, Knockout