Ischemia/reperfusion injury in microvascular surgery.

Journal Article (Journal Article;Review)

Ischemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular level. Subsequently, the pharmacotherapeutic agents used clinically and experimentally to avoid or reverse ischemia/reperfusion injury are discussed. The goal of this review is to provide a framework for understanding the expanding body of literature relevant to ischemia/reperfusion injury in microvascular surgery.

Full Text

Duke Authors

Cited Authors

  • Carroll, WR; Esclamado, RM

Published Date

  • October 2000

Published In

Volume / Issue

  • 22 / 7

Start / End Page

  • 700 - 713

PubMed ID

  • 11002326

International Standard Serial Number (ISSN)

  • 1043-3074

Digital Object Identifier (DOI)

  • 10.1002/1097-0347(200010)22:7<700::aid-hed10>;2-h


  • eng

Conference Location

  • United States