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Reconstruction of the rabbit trachea with vascularized auricular perichondrium.

Publication ,  Journal Article
Naficy, S; Esclamado, RM; Clevens, RA
Published in: Ann Otol Rhinol Laryngol
May 1996

Success in laryngotracheal reconstruction has been limited, in part, by the lack of an ideal grafting material. Perichondrium is thin, pliable, and highly vascularized and has the ability to generate new cartilage providing rigid support. These qualities make vascularized perichondrium potentially the ideal grafting material for circumferential airway stenosis. A pedicled vascularized flap of auricular perichondrium was used in a rabbit model (n = 39) to reconstruct a near-circumferential tracheal defect without a tracheostomy. A stent was used to support the reconstructed airway for 6 weeks, after which time it was removed by direct laryngoscopy. Animals were observed for an additional 6 weeks prior to sacrifice. Qualitative and quantitative histologic analysis of neochondrogenesis is reported. Vascularized perichondrium and periosteum show promise as potential grafts for reconstruction of circumferential tracheal defects.

Duke Scholars

Published In

Ann Otol Rhinol Laryngol

DOI

ISSN

0003-4894

Publication Date

May 1996

Volume

105

Issue

5

Start / End Page

356 / 362

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Tracheal Stenosis
  • Trachea
  • Surgical Flaps
  • Stents
  • Rabbits
  • Otorhinolaryngology
  • Male
  • Larynx
  • Laryngostenosis
 

Citation

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Chicago
ICMJE
MLA
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Naficy, S., Esclamado, R. M., & Clevens, R. A. (1996). Reconstruction of the rabbit trachea with vascularized auricular perichondrium. Ann Otol Rhinol Laryngol, 105(5), 356–362. https://doi.org/10.1177/000348949610500505
Naficy, S., R. M. Esclamado, and R. A. Clevens. “Reconstruction of the rabbit trachea with vascularized auricular perichondrium.Ann Otol Rhinol Laryngol 105, no. 5 (May 1996): 356–62. https://doi.org/10.1177/000348949610500505.
Naficy S, Esclamado RM, Clevens RA. Reconstruction of the rabbit trachea with vascularized auricular perichondrium. Ann Otol Rhinol Laryngol. 1996 May;105(5):356–62.
Naficy, S., et al. “Reconstruction of the rabbit trachea with vascularized auricular perichondrium.Ann Otol Rhinol Laryngol, vol. 105, no. 5, May 1996, pp. 356–62. Pubmed, doi:10.1177/000348949610500505.
Naficy S, Esclamado RM, Clevens RA. Reconstruction of the rabbit trachea with vascularized auricular perichondrium. Ann Otol Rhinol Laryngol. 1996 May;105(5):356–362.
Journal cover image

Published In

Ann Otol Rhinol Laryngol

DOI

ISSN

0003-4894

Publication Date

May 1996

Volume

105

Issue

5

Start / End Page

356 / 362

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Tracheal Stenosis
  • Trachea
  • Surgical Flaps
  • Stents
  • Rabbits
  • Otorhinolaryngology
  • Male
  • Larynx
  • Laryngostenosis