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Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus.

Publication ,  Journal Article
Esclamado, RM; Carroll, WR
Published in: Arch Otolaryngol Head Neck Surg
November 1992

Extracapsular spread of squamous cell carcinoma in cervical lymph nodes is associated with approximately 50% decrease in survival and a twofold increase in regional recurrence. This study examines the hypothesis that increased regional recurrence may be, in part, due to unrecognized microscopic perineural invasion of the nerve rootlets of the cervical plexus. Thirty patients with head and neck squamous cell carcinoma with clinically N+ necks undergoing radical neck dissection were prospectively studied. Neck dissection specimens were evaluated for extracapsular spread, and the cervical plexus rootlets were histologically examined for perineural invasion. The incidence of extracapsular spread was 83% (25 of 30 patients). Only one (4%) of 25 had involvement of the cervical plexus, and this patient had gross as well as microscopic cervical plexus invasion. Microscopic perineural spread of squamous cell carcinoma in the cervical plexus occurs infrequently when extracapsular spread is present. Routine histologic evaluation of cervical rootlets for margins is warranted only when gross tumor is in close proximity to the cervical plexus.

Duke Scholars

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

November 1992

Volume

118

Issue

11

Start / End Page

1157 / 1158

Location

United States

Related Subject Headings

  • Prospective Studies
  • Peripheral Nervous System Neoplasms
  • Otorhinolaryngology
  • Neoplasm Invasiveness
  • Neck Dissection
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Head and Neck Neoplasms
 

Citation

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MLA
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Esclamado, R. M., & Carroll, W. R. (1992). Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus. Arch Otolaryngol Head Neck Surg, 118(11), 1157–1158. https://doi.org/10.1001/archotol.1992.01880110025006
Esclamado, R. M., and W. R. Carroll. “Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus.Arch Otolaryngol Head Neck Surg 118, no. 11 (November 1992): 1157–58. https://doi.org/10.1001/archotol.1992.01880110025006.
Esclamado RM, Carroll WR. Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus. Arch Otolaryngol Head Neck Surg. 1992 Nov;118(11):1157–8.
Esclamado, R. M., and W. R. Carroll. “Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus.Arch Otolaryngol Head Neck Surg, vol. 118, no. 11, Nov. 1992, pp. 1157–58. Pubmed, doi:10.1001/archotol.1992.01880110025006.
Esclamado RM, Carroll WR. Extracapsular spread and the perineural extension of squamous cell cancer in the cervical plexus. Arch Otolaryngol Head Neck Surg. 1992 Nov;118(11):1157–1158.

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

November 1992

Volume

118

Issue

11

Start / End Page

1157 / 1158

Location

United States

Related Subject Headings

  • Prospective Studies
  • Peripheral Nervous System Neoplasms
  • Otorhinolaryngology
  • Neoplasm Invasiveness
  • Neck Dissection
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Humans
  • Head and Neck Neoplasms