Phase I evaluation of diaziquone in childhood cancer. A Pediatric Oncology Group study.

Journal Article (Journal Article)

We conducted a phase I clinical study of aziridinylbenzoquinone (Diaziquone, AZQ) given as a 4 hour infusion weekly X 4. Forty-five children with recurrent acute leukemia and 33 children with various advanced solid tumors participated. Severe myelosuppression was the dose limiting toxic effect, occurring in all patients at the upper dose levels. Gastrointestinal and hepatic toxicities were infrequent and not severe. No allergic reactions occurred. Objective tumor regression was noted in 3 of 25 patients with a CNS tumor and in 6 of 45 patients with acute leukemia. For phase II trials the recommended dosage of Diaziquone given by this schedule is 18 mg/M2/week X 4 for patients with a solid tumor, and is 30 mg/M2/week X 4 for children with acute leukemia.

Full Text

Duke Authors

Cited Authors

  • Falletta, JM; Cushing, B; Lauer, S; Bell, B; Mahoney, DH; Castleberry, R; Krance, RA

Published Date

  • May 1990

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 167 - 170

PubMed ID

  • 2384303

International Standard Serial Number (ISSN)

  • 0167-6997

Digital Object Identifier (DOI)

  • 10.1007/BF00177252


  • eng

Conference Location

  • United States