CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study.

Journal Article (Clinical Trial;Journal Article)

Children with acute lymphoblastic leukemia were randomized to one of two treatment options for CNS prophylaxis. All patients received intrathecal therapy over a one-year period with methotrexate, hydrocortisone and cytosine arabinoside. One-half of the patients also received 2400 rad cranial radiation over 2 1/2 weeks. There was no significant difference in CNS relapse rate, length of hematologic remission or survival between the two groups. No further CNS relapses have been observed for the last four years. CNS relapse was associated with subsequent disease recurrence in the 67% of patients.

Full Text

Duke Authors

Cited Authors

  • Komp, DM; Fernandez, CH; Falletta, JM; Ragab, AH; Humphrey, GB; Pullen, J; Moon, T; Shuster, J

Published Date

  • September 15, 1982

Published In

Volume / Issue

  • 50 / 6

Start / End Page

  • 1031 - 1036

PubMed ID

  • 7049344

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19820915)50:6<1031::aid-cncr2820500602>;2-7


  • eng

Conference Location

  • United States