Guanazole (NSC 1895) in the treatment of childhood leukemia

Journal Article (Journal Article)

Twenty six children with late stage acute leukemia in relapse were treated with a total of 48 courses of guanazole at a dose of 15 g/m2/dy for 5 days, given approximately every 2 wk. No complete or partial remissions were achieved in 18 evaluable patients, although 2 of 3 evaluable patients with acute myelogenous leukemia and one of 15 evaluable patients with acute lymphoblastic leukemia showed a transient decrease in the number and percentage of blast cells in the bone marrow and peripheral blood. Bone marrow depression, attributed to the guanazole therapy, occurred in all but 6 evaluable patients.

Duke Authors

Cited Authors

  • Land, VJ; Falletta, JM; McMillan, CW; Williams, TE

Published Date

  • December 1, 1974

Published In

  • Cancer Chemother.Rep.

Volume / Issue

  • 58 / 5

Start / End Page

  • 715 - 717

Citation Source

  • Scopus