Sulfonylurea treatment of insulin-independent diabetes mellitus.


Journal Article

The ultimate clinical utility of the sulfonylurea drugs in the treatment of insulin-independent diabetes mellitus will be determined only when the mechanisms of action of these agents are understood. We are presently evaluating the long-term effects of the sulfonylurea glipizide on a group of patients with insulin-independent diabetes. Our studies thus far indicate that a major effect of this drug is a potentiation of insulin action, which leads to an improvement in glucose utilization. However, glipizide, in distinction from those sulfonylureas that have been examined previously, also causes a long-term increase in glucose-stimulated insulin secretion. These effects are unrelated to diet therapy and can still be demonstrated in patients treated for more than 2 yr. Further investigation will determine whether sulfonylurea therapy can offer unique benefits to certain patients with insulin-independent diabetes.

Full Text

Duke Authors

Cited Authors

  • Feinglos, MN; Lebovitz, HE

Published Date

  • May 1, 1980

Published In

Volume / Issue

  • 29 / 5

Start / End Page

  • 488 - 494

PubMed ID

  • 6990184

Pubmed Central ID

  • 6990184

International Standard Serial Number (ISSN)

  • 0026-0495

Digital Object Identifier (DOI)

  • 10.1016/0026-0495(80)90175-4


  • eng

Conference Location

  • United States