Potentiation of insulin action: a probable mechanism for the anti-diabetic action of sulfonylurea drugs.


Journal Article

Insulin action was assessed by measuring insulin-mediated glucose disposal (KI) in 13 non-ketotic diabetic patients both before treatment and after normalization of plasma glucose by diet (5 patients) or sulfonylurea (glipizide) therapy (8 patients). While the KI of the diet-treated group was unchanged by therapy, that of the glipizide-treated group was significantly increased. The data show that chronic glipizide therapy is associated with a potentiation of insulin action, which may account for the major anti-diabetic effect of this drug.

Full Text

Duke Authors

Cited Authors

  • Lebovitz, HE; Feinglos, MN; Bucholtz, HK; Lebovitz, FL

Published Date

  • September 1, 1977

Published In

Volume / Issue

  • 45 / 3

Start / End Page

  • 601 - 604

PubMed ID

  • 903405

Pubmed Central ID

  • 903405

International Standard Serial Number (ISSN)

  • 0021-972X

Digital Object Identifier (DOI)

  • 10.1210/jcem-45-3-601


  • eng

Conference Location

  • United States