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Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs

Publication ,  Journal Article
Tripathi, RC; Fekrat, S; Tripathi, BJ; Borisuth, NSC
Published in: Drug Development Research
January 1, 1991

The uveal tract of the eye, which consists of the iris, ciliary body, and choroid, is responsible for the primary nutritional supply of the ocular structures, especially the retina and, through the production of aqueous and vitreous humors, for nourishment of avascular intraocular structures such as the lens, cornea, and trebecular meshwork. The growth factors that have been detected in the uveal tract include fibroblast growth factor, epidermal growth factor, transferrin, transforming growth factor‐β, nerve growth factor, epidermal growth factor, and insulin‐like growth factors. These mitogens in the uveal tract influence the metabolism and proliferative activity of intraocular structures, and have major implications for the health and disease of the eye. We discuss the possible therapeutic role of growth factors, as well as the prospects for, and hurdles in, drug development for their use in various ocular disorders such as degenerative and proliferative diseases, neovascularization, glaucoma, ocular ischemic syndromes, cataract, neoplasms, and wound healing well as in the modulation of HLA‐DR expression. Copyright © 1991 Wiley‐Liss, Inc.

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Published In

Drug Development Research

DOI

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1991

Volume

23

Issue

1

Start / End Page

1 / 25

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

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Tripathi, R. C., Fekrat, S., Tripathi, B. J., & Borisuth, N. S. C. (1991). Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs. Drug Development Research, 23(1), 1–25. https://doi.org/10.1002/ddr.430230102
Tripathi, R. C., S. Fekrat, B. J. Tripathi, and N. S. C. Borisuth. “Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs.” Drug Development Research 23, no. 1 (January 1, 1991): 1–25. https://doi.org/10.1002/ddr.430230102.
Tripathi RC, Fekrat S, Tripathi BJ, Borisuth NSC. Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs. Drug Development Research. 1991 Jan 1;23(1):1–25.
Tripathi, R. C., et al. “Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs.” Drug Development Research, vol. 23, no. 1, Jan. 1991, pp. 1–25. Scopus, doi:10.1002/ddr.430230102.
Tripathi RC, Fekrat S, Tripathi BJ, Borisuth NSC. Role of growth factors in the uveal tract of the eye as targeted to the development of new drugs. Drug Development Research. 1991 Jan 1;23(1):1–25.
Journal cover image

Published In

Drug Development Research

DOI

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1991

Volume

23

Issue

1

Start / End Page

1 / 25

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences