Results of high dose rate brachytherapy, anterior pelvic exenteration and external beam radiotherapy for carcinoma of the female urethra.


Journal Article

PURPOSE: We evaluated a multimodality approach to locally advanced urethral carcinoma in women. MATERIALS AND METHODS: Between August 1996 and July 1999, 6 women were treated for locally advanced carcinoma of the urethra with anterior pelvic exenteration followed by high dose 192iridium intraoperative radiation therapy. Four of the 6 patients were also treated with neoadjuvant or concomitant platinum based chemotherapy. RESULTS: Two patients had no evidence of disease, 3 had distant metastasis and 2 had local recurrence at a mean followup of 21 months (range 12 to 47). Radiation was relatively well tolerated with no major adverse events. CONCLUSIONS: High dose intraoperative brachytherapy followed by external beam radiation is relatively well tolerated. Local control seems to have improved. We must evaluate a larger cohort of patients to determine this impact of the combined modality on local control and patient survival.

Full Text

Duke Authors

Cited Authors

  • Dalbagni, G; Donat, SM; Eschwège, P; Herr, HW; Zelefsky, MJ

Published Date

  • November 2001

Published In

Volume / Issue

  • 166 / 5

Start / End Page

  • 1759 - 1761

PubMed ID

  • 11586218

Pubmed Central ID

  • 11586218

International Standard Serial Number (ISSN)

  • 0022-5347


  • eng

Conference Location

  • United States