Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.
Publication
, Journal Article
Arnoczy, GS; Ferrari, G; Goonetilleke, N; Corrah, T; Li, H; Kuruc, J; Schmitz, JL; McGee, K; Hicks, C; Eron, JJ ...
Published in: AIDS Res Hum Retroviruses
August 2012
Acute HIV-1 infection causes a rapid total body depletion of CD4(+) T cells in most individuals and HIV-1-specific CD8(+) T cell expansion in response to viral replication. A numerically high CD8 T cell response may indicate limited T cell repertoire against HIV and rapid progression. We present a detailed evaluation of an acutely infected individual with a strong HIV-1-specific CD8 T cell response targeting multiple epitopes demonstrating that the upper limit of CD8 expansion in this setting may be much higher than previously reported and was likely driven by the narrow HIV-specific response.
Duke Scholars
Published In
AIDS Res Hum Retroviruses
DOI
EISSN
1931-8405
Publication Date
August 2012
Volume
28
Issue
8
Start / End Page
789 / 792
Location
United States
Related Subject Headings
- Virology
- Male
- Humans
- HIV-1
- HIV Infections
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Adult
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Arnoczy, G. S., Ferrari, G., Goonetilleke, N., Corrah, T., Li, H., Kuruc, J., … Center for HIV/AIDS Vaccine Immunology AI067854, . (2012). Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation. AIDS Res Hum Retroviruses, 28(8), 789–792. https://doi.org/10.1089/AID.2011.0145
Arnoczy, Gretchen S., Guido Ferrari, Nilu Goonetilleke, Tumena Corrah, Hui Li, Joann Kuruc, John L. Schmitz, et al. “Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.” AIDS Res Hum Retroviruses 28, no. 8 (August 2012): 789–92. https://doi.org/10.1089/AID.2011.0145.
Arnoczy GS, Ferrari G, Goonetilleke N, Corrah T, Li H, Kuruc J, et al. Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation. AIDS Res Hum Retroviruses. 2012 Aug;28(8):789–92.
Arnoczy, Gretchen S., et al. “Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.” AIDS Res Hum Retroviruses, vol. 28, no. 8, Aug. 2012, pp. 789–92. Pubmed, doi:10.1089/AID.2011.0145.
Arnoczy GS, Ferrari G, Goonetilleke N, Corrah T, Li H, Kuruc J, Schmitz JL, McGee K, Hicks C, Eron JJ, Center for HIV/AIDS Vaccine Immunology AI067854. Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation. AIDS Res Hum Retroviruses. 2012 Aug;28(8):789–792.
Published In
AIDS Res Hum Retroviruses
DOI
EISSN
1931-8405
Publication Date
August 2012
Volume
28
Issue
8
Start / End Page
789 / 792
Location
United States
Related Subject Headings
- Virology
- Male
- Humans
- HIV-1
- HIV Infections
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Adult
- 3202 Clinical sciences
- 1103 Clinical Sciences