Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development.


Journal Article (Review)

The definition of immune correlates of protection in HIV-1 infection is pivotal to the design of successful vaccine candidates and strategies. Although significant methodological and conceptual strides have been made in our understanding of HIV-specific cellular immunity, we have not yet defined those parameters that have a role in controlling the spread of HIV infection. This review discusses the basis of our understanding of HIV-specific cellular immunity and identifies its shortcomings. Furthermore, potential protective characteristics will be proposed that may ultimately be required for an effective vaccine designed to stimulate cellular immunity against HIV-1.

Full Text

Duke Authors

Cited Authors

  • Betts, MR; Gray, CM; Cox, JH; Ferrari, G

Published Date

  • August 2006

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 505 - 516

PubMed ID

  • 16989631

Pubmed Central ID

  • 16989631

Electronic International Standard Serial Number (EISSN)

  • 1744-8395

Digital Object Identifier (DOI)

  • 10.1586/14760584.5.4.505


  • eng

Conference Location

  • England