Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.

Journal Article (Journal Article)

A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.

Full Text

Duke Authors

Cited Authors

  • Gibas, Z; Gibas, LM; Filomena, CA; Sprandio, J; Jackson, LG

Published Date

  • October 15, 1988

Published In

Volume / Issue

  • 35 / 2

Start / End Page

  • 237 - 242

PubMed ID

  • 3180025

International Standard Serial Number (ISSN)

  • 0165-4608

Digital Object Identifier (DOI)

  • 10.1016/0165-4608(88)90246-4

Language

  • eng

Conference Location

  • United States