Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.

Journal Article

A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.

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Duke Authors

Filomena, Carol Ann

Cited Authors

Gibas, Z; Gibas, LM; Filomena, CA; Sprandio, J; Jackson, LG

Published Date

October 15, 1988

Published In

Cancer Genetics and Cytogenetics

Volume / Issue

35 / 2

Start / End Page

237 - 242

PubMed ID

3180025

International Standard Serial Number (ISSN)

0165-4608

Language

Conference Location

United States