Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.
Journal Article (Journal Article)
A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.
Full Text
Duke Authors
Cited Authors
- Gibas, Z; Gibas, LM; Filomena, CA; Sprandio, J; Jackson, LG
Published Date
- October 15, 1988
Published In
Volume / Issue
- 35 / 2
Start / End Page
- 237 - 242
PubMed ID
- 3180025
International Standard Serial Number (ISSN)
- 0165-4608
Digital Object Identifier (DOI)
- 10.1016/0165-4608(88)90246-4
Language
- eng
Conference Location
- United States