Renal vacuolar H+-ATPase.

Published

Journal Article (Review)

Vacuolar H(+)-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent transport of protons. In addition to their role in acidifying the lumen of various intracellular organelles, vacuolar H(+)-ATPases fulfill special tasks in the kidney. Vacuolar H(+)-ATPases are expressed in the plasma membrane in the kidney almost along the entire length of the nephron with apical and/or basolateral localization patterns. In the proximal tubule, a high number of vacuolar H(+)-ATPases are also found in endosomes, which are acidified by the pump. In addition, vacuolar H(+)-ATPases contribute to proximal tubular bicarbonate reabsorption. The importance in final urinary acidification along the collecting system is highlighted by monogenic defects in two subunits (ATP6V0A4, ATP6V1B1) of the vacuolar H(+)-ATPase in patients with distal renal tubular acidosis. The activity of vacuolar H(+)-ATPases is tightly regulated by a variety of factors such as the acid-base or electrolyte status. This regulation is at least in part mediated by various hormones and protein-protein interactions between regulatory proteins and multiple subunits of the pump.

Full Text

Cited Authors

  • Wagner, CA; Finberg, KE; Breton, S; Marshansky, V; Brown, D; Geibel, JP

Published Date

  • October 2004

Published In

Volume / Issue

  • 84 / 4

Start / End Page

  • 1263 - 1314

PubMed ID

  • 15383652

Pubmed Central ID

  • 15383652

Electronic International Standard Serial Number (EISSN)

  • 1522-1210

International Standard Serial Number (ISSN)

  • 0031-9333

Digital Object Identifier (DOI)

  • 10.1152/physrev.00045.2003

Language

  • eng