Stepwise self-assembly of DNA tile lattices using dsDNA bridges.

Published

Journal Article

The simple helical motif of double-strand DNA (dsDNA) has typically been judged to be uninteresting for assembly in DNA-based nanotechnology applications. In this letter, we demonstrate construction of superstructures consisting of heterogeneous DNA motifs using dsDNA in conjunction with more complex, cross-tile building blocks. Incorporation of dsDNA bridges in stepwise assembly processes can be used for controlling length and directionality of superstructures and is analogous to the "reprogramming" of sticky-ends displayed on the DNA tiles. Two distinct self-assembled DNA lattices, fixed-size nanoarrays, and extended 2D crystals of nanotracks with nanobridges, are constructed and visualized by high-resolution, liquid-phase atomic force microscopy.

Full Text

Duke Authors

Cited Authors

  • Park, SH; Finkelstein, G; LaBean, TH

Published Date

  • January 2008

Published In

Volume / Issue

  • 130 / 1

Start / End Page

  • 40 - 41

PubMed ID

  • 18072780

Pubmed Central ID

  • 18072780

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja078122f

Language

  • eng