Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper.


Journal Article

Homodyne detection can dramatically enhance measurement sensitivity for weak signals. In nonlinear optical microscopy it can make accessible a range of novel, intrinsic, contrast like nonlinear absorption and nonlinear phase contrast. Here a compact and rapid pulse shaper is developed, implemented, and demonstrated for homodyne detection in nonlinear microscopy with high-repetition rate mode-locked femtosecond lasers. With this method we generate two-photon absorption (TPA) and self-phase modulation images of gold nanostars in biological samples. Simultaneous imaging of two-photon luminescence and TPA also enables us to produce two-photon quantum yield images.

Full Text

Duke Authors

Cited Authors

  • Li, B; Claytor, KE; Yuan, H; Vo-Dinh, T; Warren, WS; Fischer, MC

Published Date

  • July 2012

Published In

Volume / Issue

  • 37 / 13

Start / End Page

  • 2763 - 2765

PubMed ID

  • 22743521

Pubmed Central ID

  • 22743521

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.37.002763


  • eng