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5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck.

Publication ,  Journal Article
Triozzi, PL; Brantley, A; Fisher, S; Cole, TB; Crocker, I; Huang, AT
Published in: Cancer
March 1, 1987

Twenty-one patients with adenoid cystic carcinoma of the head and neck were treated with intravenous boluses of cyclophosphamide and vincristine and 5-day continuous intravenous infusions of 5-fluorouracil (CVF) every 4 weeks. Eight patients received CVF as palliation for recurrent or metastatic disease. A sustained complete response (107+ months) was observed in one patient; one partial response and one mixed response each also were observed. In four patients disease stabilized, and in one disease progressed. Thirteen patients received six courses of CVF in the adjuvant setting after surgery and radiation for either primary or locoregional recurrent disease. Recurrences developed in two of seven patients with primary disease and three of six patients with recurrent disease with a median follow-up 45 months (range, 20-108+). Recurrence rate and time interval to recurrence were comparable to those of well-matched historical controls. Distant metastases have not developed in patients treated with CVF in the adjuvant setting, whereas distant metastases had developed in historical controls within comparable periods of follow-up. Serious toxicities were not encountered in any patient. The authors conclude that CVF is a well-tolerated combination chemotherapy program with activity in adenoid cystic carcinoma of the head and neck. This regimen, however, has not had a major impact in the adjuvant setting in preventing recurrent disease.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 1, 1987

Volume

59

Issue

5

Start / End Page

887 / 890

Location

United States

Related Subject Headings

  • Vincristine
  • Palliative Care
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Fluorouracil
  • Female
  • Cyclophosphamide
 

Citation

APA
Chicago
ICMJE
MLA
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Triozzi, P. L., Brantley, A., Fisher, S., Cole, T. B., Crocker, I., & Huang, A. T. (1987). 5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck. Cancer, 59(5), 887–890. https://doi.org/10.1002/1097-0142(19870301)59:5<887::aid-cncr2820590505>3.0.co;2-8
Triozzi, P. L., A. Brantley, S. Fisher, T. B. Cole, I. Crocker, and A. T. Huang. “5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck.Cancer 59, no. 5 (March 1, 1987): 887–90. https://doi.org/10.1002/1097-0142(19870301)59:5<887::aid-cncr2820590505>3.0.co;2-8.
Triozzi PL, Brantley A, Fisher S, Cole TB, Crocker I, Huang AT. 5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck. Cancer. 1987 Mar 1;59(5):887–90.
Triozzi, P. L., et al. “5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck.Cancer, vol. 59, no. 5, Mar. 1987, pp. 887–90. Pubmed, doi:10.1002/1097-0142(19870301)59:5<887::aid-cncr2820590505>3.0.co;2-8.
Triozzi PL, Brantley A, Fisher S, Cole TB, Crocker I, Huang AT. 5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck. Cancer. 1987 Mar 1;59(5):887–890.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 1, 1987

Volume

59

Issue

5

Start / End Page

887 / 890

Location

United States

Related Subject Headings

  • Vincristine
  • Palliative Care
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Fluorouracil
  • Female
  • Cyclophosphamide