A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis


Journal Article

A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces. © 2003 Wiley Periodicals, Inc.

Full Text

Duke Authors

Cited Authors

  • Ercole, F; FitzGerald, M; Perera, S; Ede, N; Riley, P; Campbell, R

Published Date

  • July 1, 2003

Published In

Volume / Issue

  • 89 / 12

Start / End Page

  • 3371 - 3378

International Standard Serial Number (ISSN)

  • 0021-8995

Digital Object Identifier (DOI)

  • 10.1002/app.12574

Citation Source

  • Scopus