C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.

Published

Journal Article

C2-Symmetrical tetrahydroxyazepanes were synthesized as inhibitors for glycosidases. Tetrahydroxyazepane 1 is a non-specific inhibitor of various glycosidases, while compounds 2, 3 and 4 specifically inhibit beta-N-acetylglucosaminidase, beta-glucosidase, and alpha-fucosidase, respectively, with Ki in the micromolar range. Compound 1 is not an inhibitor of HIV/FIV proteases, but its 3,6-difluorobenzyl derivatives are moderate inhibitors of both enzymes.

Full Text

Duke Authors

Cited Authors

  • Qian, X; Morís-Varas, F; Fitzgerald, MC; Wong, CH

Published Date

  • December 1996

Published In

Volume / Issue

  • 4 / 12

Start / End Page

  • 2055 - 2069

PubMed ID

  • 9022971

Pubmed Central ID

  • 9022971

Electronic International Standard Serial Number (EISSN)

  • 1464-3391

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/s0968-0896(96)00218-0

Language

  • eng