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Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION).

Publication ,  Journal Article
Mentz, RJ; Schulte, PJ; Fleg, JL; Fiuzat, M; Kraus, WE; Piña, IL; Keteyian, SJ; Kitzman, DW; Whellan, DJ; Ellis, SJ; O'Connor, CM
Published in: Am Heart J
February 2013

BACKGROUND: The aim of this study was to investigate the clinical characteristics, exercise training response, β-blocker selectivity, and outcomes in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD). METHODS: We performed an analysis of HF-ACTION, which randomized 2,331 patients with HF having an ejection fraction of ≤35% to usual care with or without aerobic exercise training. We examined clinical characteristics and outcomes (mortality/hospitalization, mortality, cardiovascular [CV] mortality/CV hospitalization, and CV mortality/HF hospitalization) by physician-reported COPD status using adjusted Cox models and explored an interaction with exercise training. The interaction between β-blocker cardioselectivity and outcomes was investigated. RESULTS: Of patients with COPD status documented (n = 2311), 11% (n = 249) had COPD. Patients with COPD were older, had more comorbidities, and had lower use of β-blockers compared with those without COPD. At baseline, patients with COPD had lower peak oxygen consumption and higher V(E)/V(CO)(2) slope. During a median follow-up of 2.5 years, COPD was associated with increased mortality/hospitalization, mortality, and CV mortality/HF hospitalization. After multivariable adjustment, the risk of CV mortality/HF hospitalization remained increased (hazard ratio [HR] 1.46, 95% CI 1.14-1.87), whereas mortality/hospitalization (HR 1.15, 95% CI 0.96-1.37) and mortality (HR 1.33, 95% CI 0.99-1.76) were not significantly increased. There was no interaction between COPD and exercise training on outcomes or between COPD and β-blocker selectivity on mortality/hospitalization (all P > .1). CONCLUSIONS: Chronic obstructive pulmonary disease in patients with HF was associated with older age, more comorbidities, reduced exercise capacity, and increased CV mortality/HF hospitalization, but not a differential response to exercise training. β-Blocker selectivity was not associated with differences in outcome for patients with vs without COPD.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

February 2013

Volume

165

Issue

2

Start / End Page

193 / 199

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Stroke Volume
  • Pulmonary Disease, Chronic Obstructive
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
 

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Mentz, R. J., Schulte, P. J., Fleg, J. L., Fiuzat, M., Kraus, W. E., Piña, I. L., … O’Connor, C. M. (2013). Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION). Am Heart J, 165(2), 193–199. https://doi.org/10.1016/j.ahj.2012.10.029
Mentz, Robert J., Phillip J. Schulte, Jerome L. Fleg, Mona Fiuzat, William E. Kraus, Ileana L. Piña, Steven J. Keteyian, et al. “Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION).Am Heart J 165, no. 2 (February 2013): 193–99. https://doi.org/10.1016/j.ahj.2012.10.029.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

February 2013

Volume

165

Issue

2

Start / End Page

193 / 199

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Stroke Volume
  • Pulmonary Disease, Chronic Obstructive
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans