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Targeting heart failure therapeutics: a historical perspective.

Publication ,  Journal Article
Murphy, GA; Fiuzat, M; Bristow, MR
Published in: Heart Fail Clin
January 2010

This article reviews information on the role of genetic variability in the development, progression, and treatment of heart failure. It focuses primarily on genetic variation in neurohormonal systems, where adrenergic receptors and the renin-angiotensin-aldosterone system are the two most explored areas. The article also reviews the endothelin system and natriuretic peptides. Clinical trial design issues are examined, and suggestions for pharmacogenomic clinical trials are presented. Finally, lessons from the oncology field and the changing regulatory landscape are discussed.

Duke Scholars

Published In

Heart Fail Clin

DOI

ISSN

1551-7136

Publication Date

January 2010

Volume

6

Issue

1

Start / End Page

11 / 23

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Polymorphism, Genetic
  • Humans
  • Heart Failure
  • Endothelins
  • Cardiovascular System & Hematology
  • Cardiotonic Agents
  • Atrial Natriuretic Factor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murphy, G. A., Fiuzat, M., & Bristow, M. R. (2010). Targeting heart failure therapeutics: a historical perspective. Heart Fail Clin, 6(1), 11–23. https://doi.org/10.1016/j.hfc.2009.08.008
Murphy, Guinevere A., Mona Fiuzat, and Michael R. Bristow. “Targeting heart failure therapeutics: a historical perspective.Heart Fail Clin 6, no. 1 (January 2010): 11–23. https://doi.org/10.1016/j.hfc.2009.08.008.
Murphy GA, Fiuzat M, Bristow MR. Targeting heart failure therapeutics: a historical perspective. Heart Fail Clin. 2010 Jan;6(1):11–23.
Murphy, Guinevere A., et al. “Targeting heart failure therapeutics: a historical perspective.Heart Fail Clin, vol. 6, no. 1, Jan. 2010, pp. 11–23. Pubmed, doi:10.1016/j.hfc.2009.08.008.
Murphy GA, Fiuzat M, Bristow MR. Targeting heart failure therapeutics: a historical perspective. Heart Fail Clin. 2010 Jan;6(1):11–23.
Journal cover image

Published In

Heart Fail Clin

DOI

ISSN

1551-7136

Publication Date

January 2010

Volume

6

Issue

1

Start / End Page

11 / 23

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Polymorphism, Genetic
  • Humans
  • Heart Failure
  • Endothelins
  • Cardiovascular System & Hematology
  • Cardiotonic Agents
  • Atrial Natriuretic Factor