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Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia

Publication ,  Journal Article
Hixson-Wallace, JA; Fiuzat, M
Published in: Journal of Pharmacy Practice
January 1, 1998

Drug-induced thrombocytopenia has been reported with cimetidine, ranitidine, and famotidine. The mechanism for this rare adverse event remains unclear despite several suggested explanations. Cross-reactivity between the H2 receptor antagonists has been suggested; however, our report suggests it may not necessarily occur between all H2 receptor antagonists. Exclusion of all H2 receptor antagonist therapy may not be necessary despite a patient's history of previously induced thrombocytopenia, and administration of an alternative H2 receptor antagonist may be appropriate when essential for management of the patient.

Duke Scholars

Published In

Journal of Pharmacy Practice

DOI

ISSN

0897-1900

Publication Date

January 1, 1998

Volume

11

Issue

1

Start / End Page

2 / 3

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1117 Public Health and Health Services
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Hixson-Wallace, J. A., & Fiuzat, M. (1998). Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia. Journal of Pharmacy Practice, 11(1), 2–3. https://doi.org/10.1177/089719009801100101
Hixson-Wallace, J. A., and M. Fiuzat. “Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia.” Journal of Pharmacy Practice 11, no. 1 (January 1, 1998): 2–3. https://doi.org/10.1177/089719009801100101.
Hixson-Wallace JA, Fiuzat M. Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia. Journal of Pharmacy Practice. 1998 Jan 1;11(1):2–3.
Hixson-Wallace, J. A., and M. Fiuzat. “Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia.” Journal of Pharmacy Practice, vol. 11, no. 1, Jan. 1998, pp. 2–3. Scopus, doi:10.1177/089719009801100101.
Hixson-Wallace JA, Fiuzat M. Histamine-2 (H2) receptor antagonists may not necessarily cross-react to induce thrombocytopenia. Journal of Pharmacy Practice. 1998 Jan 1;11(1):2–3.
Journal cover image

Published In

Journal of Pharmacy Practice

DOI

ISSN

0897-1900

Publication Date

January 1, 1998

Volume

11

Issue

1

Start / End Page

2 / 3

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1117 Public Health and Health Services
  • 1115 Pharmacology and Pharmaceutical Sciences