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Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome.

Publication ,  Journal Article
Ray, P; Acheson, D; Chitrakar, R; Cnaan, A; Gibbs, K; Hirschman, GH; Christen, E; Trachtman, H
Published in: J Am Soc Nephrol
March 2002

Diarrhea-associated hemolytic uremic syndrome (D+HUS) is characterized by endothelial injury and activation of inflammatory cytokines. Basic fibroblast growth factor (bFGF) is an angiogenic peptide released in response to vascular damage. The plasma concentrations and urinary excretion of bFGF during the course of D+HUS were determined, in comparison with the levels of various inflammatory cytokines, and changes were correlated with clinical and laboratory features of the disease. Serial plasma and urine samples were collected from 31 children with D+HUS, during the acute (days 1 to 7 of hospitalization) and recovery (through day 60 after discharge from the hospital) phases of the disease. The patients were enrolled in the multicenter trial of SYNSORB Pk (SYNSORB Biotech, Calgary, Alberta, Canada) treatment for D+HUS. bFGF, interleukin-1alpha (IL-1alpha), IL-8, and tumor necrosis factor-alpha levels were determined with enzyme-linked immunosorbent assays. bFGF was detected in urine and plasma samples more frequently than were IL-1alpha, IL-8, and tumor necrosis factor-alpha. There was an acute increase in urinary bFGF excretion, which returned to normal during convalescence. Urinary excretion of bFGF during the acute phase was higher among patients who required dialysis, compared with those who did not (48.9 +/- 15.0 and 28.9 +/- 9.0 pg/ml, respectively; P < 0.05). Plasma bFGF concentrations were persistently elevated throughout the period of hospitalization and the follow-up period among patients with D+HUS. Urinary excretion and plasma levels of bFGF were comparable for the SYNSORB Pk-treated (n = 19) and placebo-treated (n = 12) groups. Measurements of urinary and plasma concentrations of bFGF among patients with D+HUS may be useful indices for assessment of the severity of acute renal disease and the timing and adequacy of the systemic angiogenic process during early convalescence.

Duke Scholars

Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

March 2002

Volume

13

Issue

3

Start / End Page

699 / 707

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Osmolar Concentration
  • Interleukin-8
  • Interleukin-1
  • Infant
  • Humans
  • Hemolytic-Uremic Syndrome
  • Fibroblast Growth Factor 2
  • Diarrhea
  • Cytokines
 

Citation

APA
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ICMJE
MLA
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Ray, P., Acheson, D., Chitrakar, R., Cnaan, A., Gibbs, K., Hirschman, G. H., … Trachtman, H. (2002). Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol, 13(3), 699–707. https://doi.org/10.1681/ASN.V133699
Ray, Patricio, David Acheson, Ramona Chitrakar, Avital Cnaan, Kathleen Gibbs, Gladys H. Hirschman, Erica Christen, and Howard Trachtman. “Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome.J Am Soc Nephrol 13, no. 3 (March 2002): 699–707. https://doi.org/10.1681/ASN.V133699.
Ray P, Acheson D, Chitrakar R, Cnaan A, Gibbs K, Hirschman GH, et al. Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol. 2002 Mar;13(3):699–707.
Ray, Patricio, et al. “Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome.J Am Soc Nephrol, vol. 13, no. 3, Mar. 2002, pp. 699–707. Pubmed, doi:10.1681/ASN.V133699.
Ray P, Acheson D, Chitrakar R, Cnaan A, Gibbs K, Hirschman GH, Christen E, Trachtman H. Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol. 2002 Mar;13(3):699–707.

Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

March 2002

Volume

13

Issue

3

Start / End Page

699 / 707

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Osmolar Concentration
  • Interleukin-8
  • Interleukin-1
  • Infant
  • Humans
  • Hemolytic-Uremic Syndrome
  • Fibroblast Growth Factor 2
  • Diarrhea
  • Cytokines