Membranoproliferative glomerulonephritis type I, mixed cryoglobulinemia and lymphoma in the absence of hepatitis C infection.

Journal Article (Journal Article)

Chronic hepatitis C virus infection has been linked to cryoglobulinemia, membranoproliferative glomerulonephritis, and malignant B-cell lymphoproliferation, suggesting a possible pathogenetic link between these disorders. We report a patient with the latter clinical triad in the absence of hepatitis C infection. We postulate that the persistent and dysregulated immunologic activity associated with chronic antigen stimulation, inflammation and/or B-cell malignancy induces nephritogenic autoantibodies, including cryoglobulins, that produce a similar clinical syndrome in genetically susceptible individuals.

Full Text

Duke Authors

Cited Authors

  • Rosas, SE; Tomaszewski, JE; Feldman, HI; Foster, MH

Published Date

  • 1999

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 599 - 604

PubMed ID

  • 10575191

International Standard Serial Number (ISSN)

  • 0250-8095

Digital Object Identifier (DOI)

  • 10.1159/000013527


  • eng

Conference Location

  • Switzerland