S-nitrosylation of Ras in breast cancer.

Published online

Journal Article

Elevated expression of nitric oxide synthase 2 has been recently shown to correlate with poor survival in estrogen receptor-negative breast cancer. In an article in Breast Cancer Research, Switzer and colleagues identify the transcription factor Ets-1 as a critical mediator of nitric oxide-dependent oncogenic gene expression in basal-like breast cancer. This pathway is driven by S-nitrosylation of wild-type Ras, which leads to mitogen-activated protein kinase-dependent phosphorylation and activation of Ets-1. These results establish a new role for S-nitrosylation in mediating an aggressive breast cancer phenotype.

Full Text

Duke Authors

Cited Authors

  • Marshall, HE; Foster, MW

Published Date

  • November 12, 2012

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 113 -

PubMed ID

  • 23167903

Electronic International Standard Serial Number (EISSN)

  • 1465-542X

Digital Object Identifier (DOI)

  • 10.1186/bcr3331

Language

  • eng

Conference Location

  • England