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Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.

Publication ,  Journal Article
Andersen, PS; Pedersen, JK; Fode, P; Skov, RL; Fowler, VG; Stegger, M; Christensen, K
Published in: J Infect Dis
October 2012

BACKGROUND: Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. METHODS: Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. RESULTS: The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. CONCLUSION: In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

October 2012

Volume

206

Issue

8

Start / End Page

1178 / 1184

Location

United States

Related Subject Headings

  • Twins
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prevalence
  • Molecular Typing
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Female
 

Citation

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Andersen, P. S., Pedersen, J. K., Fode, P., Skov, R. L., Fowler, V. G., Stegger, M., & Christensen, K. (2012). Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins. J Infect Dis, 206(8), 1178–1184. https://doi.org/10.1093/infdis/jis491
Andersen, Paal Skytt, Jacob Krabbe Pedersen, Peder Fode, Robert L. Skov, Vance G. Fowler, Marc Stegger, and Kaare Christensen. “Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.J Infect Dis 206, no. 8 (October 2012): 1178–84. https://doi.org/10.1093/infdis/jis491.
Andersen PS, Pedersen JK, Fode P, Skov RL, Fowler VG, Stegger M, et al. Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins. J Infect Dis. 2012 Oct;206(8):1178–84.
Andersen, Paal Skytt, et al. “Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.J Infect Dis, vol. 206, no. 8, Oct. 2012, pp. 1178–84. Pubmed, doi:10.1093/infdis/jis491.
Andersen PS, Pedersen JK, Fode P, Skov RL, Fowler VG, Stegger M, Christensen K. Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins. J Infect Dis. 2012 Oct;206(8):1178–1184.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

October 2012

Volume

206

Issue

8

Start / End Page

1178 / 1184

Location

United States

Related Subject Headings

  • Twins
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prevalence
  • Molecular Typing
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Female