Skip to main content

Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography.

Publication ,  Journal Article
Rasmussen, RV; Høst, U; Arpi, M; Hassager, C; Johansen, HK; Korup, E; Schønheyder, HC; Berning, J; Gill, S; Rosenvinge, FS; Fowler, VG ...
Published in: Eur J Echocardiogr
June 2011

AIMS: Staphylococcus aureus infective endocarditis (IE) is a critical medical condition associated with a high morbidity and mortality. In the present study, we prospectively evaluated the importance of screening with echocardiography in an unselected S. aureus bacteraemia (SAB) population. METHODS AND RESULTS: From 1 January 2009 to 31 August 2010, a total of 244 patients with SAB at six Danish hospitals underwent screening echocardiography. The inclusion rate was 73% of all eligible patients (n= 336), and 53 of the 244 included patients (22%; 95% CI: 17-27%) were diagnosed with definite IE. In patients with native heart valves the prevalence was 19% (95% CI: 14-25%) compared with 38% (95% CI: 20-55%) in patients with prosthetic heart valves and/or cardiac rhythm management devices (P= 0.02). No difference was found between Main Regional Hospitals and Tertiary Cardiac Hospitals, 20 vs. 23%, respectively (NS). The prevalence of IE in high-risk patients with one or more predisposing condition or clinical evidence of IE were significantly higher compared with low-risk patients with no additional risk factors (38 vs. 5%; P < 0.001). IE was associated with a higher 6 months mortality, 14(26%) vs. 28(15%) in SAB patients without IE, respectively (P < 0.05). CONCLUSION: SAB patients carry a high risk for development of IE, which is associated with a worse prognosis compared with uncomplicated SAB. The presenting symptoms and clinical findings associated with IE are often non-specific and echocardiography should always be considered as part of the initial evaluation of SAB patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur J Echocardiogr

DOI

EISSN

1532-2114

Publication Date

June 2011

Volume

12

Issue

6

Start / End Page

414 / 420

Location

England

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics as Topic
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Odds Ratio
  • Mass Screening
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rasmussen, R. V., Høst, U., Arpi, M., Hassager, C., Johansen, H. K., Korup, E., … Bruun, N. E. (2011). Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography. Eur J Echocardiogr, 12(6), 414–420. https://doi.org/10.1093/ejechocard/jer023
Rasmussen, Rasmus V., Ulla Høst, Magnus Arpi, Christian Hassager, Helle K. Johansen, Eva Korup, Henrik C. Schønheyder, et al. “Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography.Eur J Echocardiogr 12, no. 6 (June 2011): 414–20. https://doi.org/10.1093/ejechocard/jer023.
Rasmussen RV, Høst U, Arpi M, Hassager C, Johansen HK, Korup E, et al. Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography. Eur J Echocardiogr. 2011 Jun;12(6):414–20.
Rasmussen, Rasmus V., et al. “Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography.Eur J Echocardiogr, vol. 12, no. 6, June 2011, pp. 414–20. Pubmed, doi:10.1093/ejechocard/jer023.
Rasmussen RV, Høst U, Arpi M, Hassager C, Johansen HK, Korup E, Schønheyder HC, Berning J, Gill S, Rosenvinge FS, Fowler VG, Møller JE, Skov RL, Larsen CT, Hansen TF, Mard S, Smit J, Andersen PS, Bruun NE. Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography. Eur J Echocardiogr. 2011 Jun;12(6):414–420.

Published In

Eur J Echocardiogr

DOI

EISSN

1532-2114

Publication Date

June 2011

Volume

12

Issue

6

Start / End Page

414 / 420

Location

England

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics as Topic
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Odds Ratio
  • Mass Screening