Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia.
(Clinical Trial;Journal Article)
In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were >or=1 microg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.
McCalla, C; Smyth, DS; Robinson, DA; Steenbergen, J; Luperchio, SA; Moise, PA; Fowler, VG; Sakoulas, G
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