Staphylococcus aureus bacteremia and endocarditis

Journal Article

Staphylococcus aureus is a leading cause of bacteremia and endocarditis. Over the past several years, the frequency of Saureus bacteremia (SAB) has increased dramatically. This increasing frequency, coupled with increasing rates of antibiotic resistance, has renewed interest in this serious, common infection. S. aureus is a unique pathogen because of its virulent properties, its protean manifestations, and its ability to cause endocarditis on architecturally normal cardiac valves. Although the possibility of underlying endocarditis arises in virtually every patient with SAB, only a minority of baceremic patients will actually have cardiac involvement. Distinguishing patients with S. aureus infective endocarditis (IE) from those with uncomplicated SAB is essential, but often difficult. In this review, the authors summarize recent changes in the epidemiology of SAB and IE, discuss the challenges in distinguishing SAB from IE, and discuss current trends in the management of patients with SAB and IE.

Full Text

Duke Authors

Cited Authors

  • Petti, CA; Jr, VGF

Published Date

  • 2002

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 413 - 435

International Standard Serial Number (ISSN)

  • 0891-5520

Digital Object Identifier (DOI)

  • 10.1016/S0891-5520(01)00003-4