Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.


Journal Article (Review)

The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

Full Text

Duke Authors

Cited Authors

  • Losick, VP; Morris, LX; Fox, DT; Spradling, A

Published Date

  • July 19, 2011

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 159 - 171

PubMed ID

  • 21763616

Pubmed Central ID

  • 21763616

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2011.06.018


  • eng

Conference Location

  • United States