Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.
Publication
, Journal Article
Losick, VP; Morris, LX; Fox, DT; Spradling, A
Published in: Dev Cell
July 19, 2011
The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.
Duke Scholars
Published In
Dev Cell
DOI
EISSN
1878-1551
Publication Date
July 19, 2011
Volume
21
Issue
1
Start / End Page
159 / 171
Location
United States
Related Subject Headings
- Stem Cells
- Stem Cell Niche
- Drosophila
- Developmental Biology
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Losick, V. P., Morris, L. X., Fox, D. T., & Spradling, A. (2011). Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Dev Cell, 21(1), 159–171. https://doi.org/10.1016/j.devcel.2011.06.018
Losick, Vicki P., Lucy X. Morris, Donald T. Fox, and Allan Spradling. “Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.” Dev Cell 21, no. 1 (July 19, 2011): 159–71. https://doi.org/10.1016/j.devcel.2011.06.018.
Losick VP, Morris LX, Fox DT, Spradling A. Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Dev Cell. 2011 Jul 19;21(1):159–71.
Losick, Vicki P., et al. “Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.” Dev Cell, vol. 21, no. 1, July 2011, pp. 159–71. Pubmed, doi:10.1016/j.devcel.2011.06.018.
Losick VP, Morris LX, Fox DT, Spradling A. Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Dev Cell. 2011 Jul 19;21(1):159–171.
Published In
Dev Cell
DOI
EISSN
1878-1551
Publication Date
July 19, 2011
Volume
21
Issue
1
Start / End Page
159 / 171
Location
United States
Related Subject Headings
- Stem Cells
- Stem Cell Niche
- Drosophila
- Developmental Biology
- Animals
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences