Linkage of the gene controlling the synthesis of the fourth component of complement to the major histocompatibility complex of the guinea pig


Journal Article

C4-deficient (C4D) guinea pigs are lacking in C4 synthesis, a condition that appears to be caused by a structural gene defect. This defect is inherited as a simple autosomal recessive trait. We have demonstrated linkage between C4D and the major histocompatibility complex of the guinea pig (GPLA). Inbred C4D and inbred strain 13 guinea pigs appear to have the same GPLA haplotype. The use of these two strains should provide an animal model for reconstitution studies of C4 synthesis and for studied exploring the possible role of C4 in cellular and humoral immune responses. © 1976 Springer-Verlag New York Inc.

Full Text

Cited Authors

  • Shevach, EM; Frank, MM; Green, I

Published Date

  • December 1, 1976

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 595 - 601

Electronic International Standard Serial Number (EISSN)

  • 1432-1211

International Standard Serial Number (ISSN)

  • 0093-7711

Digital Object Identifier (DOI)

  • 10.1007/BF01576989

Citation Source

  • Scopus