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Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men.

Publication ,  Journal Article
Kim, HS; Moreira, DM; Jayachandran, J; Gerber, L; Bañez, LL; Vollmer, RT; Lark, AL; Donovan, MJ; Powell, D; Khan, FM; Freedland, SJ
Published in: Prostate Cancer Prostatic Dis
September 2011

A wide array of biomarkers is being investigated as predictors of prostate cancer (PCa) diagnosis and recurrence. We compared the expression of a small panel of these biomarkers as a function of race among men undergoing radical prostatectomy (RP). Prostate needle biopsy specimens from 131 patients treated with RP at the Durham Veterans Affairs Medical Center were hematoxylin and eosin stained and immunofluorescent assayed for α-methylacyl CoA racemase (AMACR), androgen receptor (AR) and Ki67. Proprietary image analysis was used to identify six biometric feature combinations that were significantly associated with progression in a previous study. Analysis of population characteristics, stratified by race, was performed using rank-sum and χ(2)-test. The effect of race on expression of these biomarker profiles was analyzed using multivariate linear regression. All six biomarker features were expressed at higher levels in black men than white men, with Norm AR (P=0.006) and Ki67 (P=0.02) attaining statistical significance. On multivariate analysis, all markers were expressed at higher levels in black men, with Norm AR (P=0.001), Ki67 (P=0.007) and Ki67/lum (P=0.022) reaching significance. These data support the hypothesis that PCa may be biologically more aggressive among black men.

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Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2011

Volume

14

Issue

3

Start / End Page

262 / 265

Location

England

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Receptors, Androgen
  • Racemases and Epimerases
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Multivariate Analysis
  • Middle Aged
  • Male
 

Citation

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Kim, H. S., Moreira, D. M., Jayachandran, J., Gerber, L., Bañez, L. L., Vollmer, R. T., … Freedland, S. J. (2011). Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men. Prostate Cancer Prostatic Dis, 14(3), 262–265. https://doi.org/10.1038/pcan.2011.18
Kim, H. S., D. M. Moreira, J. Jayachandran, L. Gerber, L. L. Bañez, R. T. Vollmer, A. L. Lark, et al. “Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men.Prostate Cancer Prostatic Dis 14, no. 3 (September 2011): 262–65. https://doi.org/10.1038/pcan.2011.18.
Kim HS, Moreira DM, Jayachandran J, Gerber L, Bañez LL, Vollmer RT, et al. Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men. Prostate Cancer Prostatic Dis. 2011 Sep;14(3):262–5.
Kim, H. S., et al. “Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men.Prostate Cancer Prostatic Dis, vol. 14, no. 3, Sept. 2011, pp. 262–65. Pubmed, doi:10.1038/pcan.2011.18.
Kim HS, Moreira DM, Jayachandran J, Gerber L, Bañez LL, Vollmer RT, Lark AL, Donovan MJ, Powell D, Khan FM, Freedland SJ. Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men. Prostate Cancer Prostatic Dis. 2011 Sep;14(3):262–265.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

September 2011

Volume

14

Issue

3

Start / End Page

262 / 265

Location

England

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Receptors, Androgen
  • Racemases and Epimerases
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Multivariate Analysis
  • Middle Aged
  • Male