Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men.

Published

Journal Article

A wide array of biomarkers is being investigated as predictors of prostate cancer (PCa) diagnosis and recurrence. We compared the expression of a small panel of these biomarkers as a function of race among men undergoing radical prostatectomy (RP). Prostate needle biopsy specimens from 131 patients treated with RP at the Durham Veterans Affairs Medical Center were hematoxylin and eosin stained and immunofluorescent assayed for α-methylacyl CoA racemase (AMACR), androgen receptor (AR) and Ki67. Proprietary image analysis was used to identify six biometric feature combinations that were significantly associated with progression in a previous study. Analysis of population characteristics, stratified by race, was performed using rank-sum and χ(2)-test. The effect of race on expression of these biomarker profiles was analyzed using multivariate linear regression. All six biomarker features were expressed at higher levels in black men than white men, with Norm AR (P=0.006) and Ki67 (P=0.02) attaining statistical significance. On multivariate analysis, all markers were expressed at higher levels in black men, with Norm AR (P=0.001), Ki67 (P=0.007) and Ki67/lum (P=0.022) reaching significance. These data support the hypothesis that PCa may be biologically more aggressive among black men.

Full Text

Duke Authors

Cited Authors

  • Kim, HS; Moreira, DM; Jayachandran, J; Gerber, L; Bañez, LL; Vollmer, RT; Lark, AL; Donovan, MJ; Powell, D; Khan, FM; Freedland, SJ

Published Date

  • September 2011

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 262 - 265

PubMed ID

  • 21519348

Pubmed Central ID

  • 21519348

Electronic International Standard Serial Number (EISSN)

  • 1476-5608

Digital Object Identifier (DOI)

  • 10.1038/pcan.2011.18

Language

  • eng

Conference Location

  • England