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Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.

Publication ,  Journal Article
Bifani, P; Mathema, B; Campo, M; Moghazeh, S; Nivin, B; Shashkina, E; Driscoll, J; Munsiff, SS; Frothingham, R; Kreiswirth, BN
Published in: Emerg Infect Dis
2001

A distinct branch of the Mycobacterium tuberculosis W phylogenetic lineage (W14 group) has been identified and characterized by various genotyping techniques. The W14 group comprises three strain variants: W14, W23, and W26, which accounted for 26 clinical isolates from the New York City metropolitan area. The W14 group shares a unique IS6110 hybridizing banding motif as well as distinct polymorphic GC-rich repetitive sequence and variable number tandem repeat patterns. All W14 group members have high levels of streptomycin resistance. When the streptomycin resistance rpsL target gene was sequenced, all members of this strain family had an identical mutation in codon 43. Patients infected with the W14 group were primarily of non- Hispanic black origin (77%); all were US-born. Including HIV positivity, 84% of the patients had at least one known risk factor for tuberculosis.

Duke Scholars

Published In

Emerg Infect Dis

DOI

ISSN

1080-6040

Publication Date

2001

Volume

7

Issue

5

Start / End Page

842 / 848

Location

United States

Related Subject Headings

  • Tuberculosis, Multidrug-Resistant
  • Tuberculosis
  • Streptomycin
  • New York City
  • Mycobacterium tuberculosis
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Bifani, P., Mathema, B., Campo, M., Moghazeh, S., Nivin, B., Shashkina, E., … Kreiswirth, B. N. (2001). Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. Emerg Infect Dis, 7(5), 842–848. https://doi.org/10.3201/eid0705.010512
Bifani, P., B. Mathema, M. Campo, S. Moghazeh, B. Nivin, E. Shashkina, J. Driscoll, S. S. Munsiff, R. Frothingham, and B. N. Kreiswirth. “Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.Emerg Infect Dis 7, no. 5 (2001): 842–48. https://doi.org/10.3201/eid0705.010512.
Bifani P, Mathema B, Campo M, Moghazeh S, Nivin B, Shashkina E, et al. Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. Emerg Infect Dis. 2001;7(5):842–8.
Bifani, P., et al. “Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.Emerg Infect Dis, vol. 7, no. 5, 2001, pp. 842–48. Pubmed, doi:10.3201/eid0705.010512.
Bifani P, Mathema B, Campo M, Moghazeh S, Nivin B, Shashkina E, Driscoll J, Munsiff SS, Frothingham R, Kreiswirth BN. Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. Emerg Infect Dis. 2001;7(5):842–848.

Published In

Emerg Infect Dis

DOI

ISSN

1080-6040

Publication Date

2001

Volume

7

Issue

5

Start / End Page

842 / 848

Location

United States

Related Subject Headings

  • Tuberculosis, Multidrug-Resistant
  • Tuberculosis
  • Streptomycin
  • New York City
  • Mycobacterium tuberculosis
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Male
  • Humans