The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.


Journal Article

The GroES antigen provokes a strong immune response in human beings with tuberculosis or leprosy. We cloned and sequenced the Mycobacterium avium and Mycobacterium paratuberculosis GroES genes. M. avium and M. paratuberculosis have identical GroES sequences which differ from other mycobacterial species. This supports the current formal designation of M. paratuberculosis as M. avium subsp. paratuberculosis. Immunodominant epitopes from Mycobacterium tuberculosis GroES are conserved in M. avium, but some Mycobacterium leprae epitopes are distinct. GroES is unlikely to be specific as a serologic or skin test reagent, but may be an appropriate component of a broad mycobacterial vaccine.

Full Text

Duke Authors

Cited Authors

  • Cobb, AJ; Frothingham, R

Published Date

  • June 1, 1999

Published In

Volume / Issue

  • 67 / 1

Start / End Page

  • 31 - 35

PubMed ID

  • 10392775

Pubmed Central ID

  • 10392775

International Standard Serial Number (ISSN)

  • 0378-1135

Digital Object Identifier (DOI)

  • 10.1016/s0378-1135(99)00019-x


  • eng

Conference Location

  • Netherlands